Les résultats de la thèse sur le sol-gel mydriatique disponibles !

Unither n’a cessé de travailler et investir ses efforts dans la recherche et le développement ophtalmologique, avec pour but principal de faciliter la vie des patients.

Le savoir-faire d’Unither se traduit à travers des développements sur les sites de Coutances et Amiens, ainsi que les laboratoires de Bordeaux (France) et Wuhan (Chine), mais aussi les travaux de recherches sur la technologie Sol-Gel menés depuis 2012 (6 publications scientifiques internationales) et initiés par Ni Zeng, Responsable du Développement pour la Chine.

Les résultats de la thèse sur le sol-gel mydriatique de Pierre-Louis Destruel, Chargé de développement pour la Chine, sont désormais disponibles.

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Titre : « In Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics »

Abstract: Mydriasis is required prior to many eye examinations and ophthalmic surgeries. Nowadays, phenylephrine hydrochloride (PHE) and tropicamide (TPC) are extensively used to induce mydriasis. Several pharmaceutic dosage forms of these two active ingredients have been described. However, no optimal therapeutic strategy has reached the market. The present work focuses on the formulation and evaluation of a mucoadhesive ion-activated in situ gelling delivery system based on gellan gum and hydroxyethylcellulose (HEC) for the delivery of phenylephrine and tropicamide. First, in vitro drug release was studied to assess appropriate sustained drug delivery on the ocular surface region. Drug release mechanisms were explored and explained using mathematical modeling. Then, in situ gelling delivery systems were visualized using scanning electron microscopy illustrating the drug release phenomena involved. Afterward, cytotoxicity of the developed formulations was studied and compared with those of commercially available eye drops. Human epithelial corneal cells were used. Finally, mydriasis intensity and kinetic was investigated in vivo. Mydriasis pharmacodynamics was studied by non-invasive optical imaging on vigilant rabbits, allowing eye blinking and nasolacrimal drainage to occur physiologically. In situ gelling delivery systems mydriasis proles exhibited a signicant increase of intensity and duration compared with those of conventional eye drops. Ecient mydriasis was achieved following the administration of a single drop of in situ gel reducing the required amount of administered active ingredients by four- to eight-fold compared with classic eye drop regimen.