The results of the mydriatic sol-gel thesis available now!

Unither keeps on working and investing its efforts in ophthalmological research and development, with the main aim of making patients’ lives easier.

Unither's know-how is expressed through developments on the Coutances and Amiens plants, as well as the laboratories of Bordeaux (France) and Wuhan (China); but also research work on the Sol-Gel technology carried out since 2012 (6 international scientific publications) and initiated by Ni Zeng, General Development Manager China.

The results of the thesis on the mydriatic sol-gel developed by Pierre-Louis Destruel, Development Project Manager China, are now available on our website.

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Title: « In Situ Gelling Ophthalmic Drug Delivery System for the Optimization of Diagnostic and Preoperative Mydriasis: In Vitro Drug Release, Cytotoxicity and Mydriasis Pharmacodynamics »

Abstract: Mydriasis is required prior to many eye examinations and ophthalmic surgeries. Nowadays, phenylephrine hydrochloride (PHE) and tropicamide (TPC) are extensively used to induce mydriasis. Several pharmaceutic dosage forms of these two active ingredients have been described. However, no optimal therapeutic strategy has reached the market. The present work focuses on the formulation and evaluation of a mucoadhesive ion-activated in situ gelling delivery system based on gellan gum and hydroxyethylcellulose (HEC) for the delivery of phenylephrine and tropicamide. First, in vitro drug release was studied to assess appropriate sustained drug delivery on the ocular surface region. Drug release mechanisms were explored and explained using mathematical modeling. Then, in situ gelling delivery systems were visualized using scanning electron microscopy illustrating the drug release phenomena involved. Afterward, cytotoxicity of the developed formulations was studied and compared with those of commercially available eye drops. Human epithelial corneal cells were used. Finally, mydriasis intensity and kinetic was investigated in vivo. Mydriasis pharmacodynamics was studied by non-invasive optical imaging on vigilant rabbits, allowing eye blinking and nasolacrimal drainage to occur physiologically. In situ gelling delivery systems mydriasis proles exhibited a signicant increase of intensity and duration compared with those of conventional eye drops. Ecient mydriasis was achieved following the administration of a single drop of in situ gel reducing the required amount of administered active ingredients by four- to eight-fold compared with classic eye drop regimen.