{"id":31591,"date":"2026-01-29T11:12:19","date_gmt":"2026-01-29T10:12:19","guid":{"rendered":"https:\/\/www.unither-pharma.com\/publication\/carragelose-scientific-publications\/"},"modified":"2026-03-18T16:06:53","modified_gmt":"2026-03-18T15:06:53","slug":"carragelose-scientific-publications","status":"publish","type":"publication","link":"https:\/\/www.unither-pharma.com\/pt-br\/publication\/carragelose-scientific-publications\/","title":{"rendered":"Publica\u00e7\u00f5es cient\u00edficas sobre Carragelose\u00ae"},"content":{"rendered":"\r\n
\r\n

Esta lista re\u00fane as principais publica\u00e7\u00f5es cient\u00edficas sobre a iota-carragenina e suas aplica\u00e7\u00f5es nos campos da imunologia e virologia.
Inclui estudos cl\u00ednicos, pr\u00e9-cl\u00ednicos e in vitro, an\u00e1lises de dados e revis\u00f5es da literatura publicadas em revistas internacionais revisadas por pares ou apresentadas em confer\u00eancias cient\u00edficas.<\/p>\r\n

Os trabalhos apresentados abrangem doen\u00e7as otorrinolaringol\u00f3gicas e respirat\u00f3rias, infec\u00e7\u00f5es virais (resfriados, gripe, SARS-CoV-2), bem como os usos profil\u00e1ticos e terap\u00eauticos de dispositivos e formula\u00e7\u00f5es \u00e0 base de iota-carragenina.
As publica\u00e7\u00f5es s\u00e3o classificadas por ano, \u00e1rea e tipo de estudo para facilitar a leitura e a consulta.<\/p>\r\n

Esta bibliografia reflete o estado atual do conhecimento cient\u00edfico dispon\u00edvel e tem como objetivo fornecer uma fonte de informa\u00e7\u00e3o transparente e documentada para profissionais de sa\u00fade, pesquisadores, parceiros industriais e partes interessadas institucionais.<\/p>\r\n<\/figure>\r\n\r\n

 <\/p>\r\n\r\n

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Ano<\/th>\r\nSe\u00e7\u00e3o<\/th>\r\nTipo<\/th>\r\nT\u00edtulo<\/th>\r\nRefer\u00eancia<\/th>\r\nDOI \/ Lien<\/th>\r\n<\/tr>\r\n<\/thead>\r\n
2025<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nProphylactic Intranasal Treatment with Iota-Carrageenan for Acute Upper Respiratory Tract Viral Infections<\/td>\r\nOpen Journal of Respiratory Diseases, 2025, 15(1), 35-47<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2024<\/td>\r\nImmunology Marinomed<\/td>\r\nPreprint<\/td>\r\nDemonstration of a decongestant effect of Coldamaris Akut compared to saline nasal spray in participants suffering from seasonal allergic rhinitis<\/td>\r\nUnger-Manhart, N. et al., medRxiv 2024.05.03.24306805<\/td>\r\nhttps:\/\/doi.org\/10.1101\/2024.05.03.24306805<\/a><\/td>\r\n<\/tr>\r\n
2024<\/td>\r\nImmunology Marinomed<\/td>\r\nJournal<\/td>\r\nCarrageenan-Containing Nasal Spray Alleviates Allergic Symptoms in Participants with Grass Pollen Allergy: A Randomized, Controlled, Crossover Clinical Trial<\/td>\r\nUnger-Manhart, N. et al., Int J Gen Med. 2024;17:419-428<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2023<\/td>\r\nImmunology Marinomed<\/td>\r\nPoster<\/td>\r\nDecongestant effect of treatment with sorbitol-containing Carragelose\u00ae nasal spray (Poster)<\/td>\r\nN. Unger-Manhart et al. 2023<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2023<\/td>\r\nImmunology Marinomed<\/td>\r\nPoster<\/td>\r\nCarragelose\u00ae nasal spray is effective in reducing allergic nasal symptoms (Poster)<\/td>\r\nN. Unger-Manhart et al. 2023<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2023<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nIota-Carrageenan Inhibits Replication of the SARS-CoV-2 Variants of Concern Omicron BA.1, BA.2 and BA.5<\/td>\r\nSetz, C. et al., Nutraceuticals 2023, 3, 315-328<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2023<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nBiological activity of algal derived carrageenan: A comprehensive review in light of human health and disease<\/td>\r\nPradhan et al., International Journal of Biological Macromolecules, 238 (2023), 124085<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2022<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nIota-carrageenan extracted from red algae is a potent inhibitor of SARS\u2010CoV-2 infection in reconstituted human airway epithelia<\/td>\r\nBovard et al., Biochemistry and Biophysics Reports, Volume 29, 2022, 101187<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2021<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nIota-Carrageenan Inhibits Replication of SARS-CoV-2 and the Respective Variants of Concern Alpha, Beta, Gamma and Delta<\/td>\r\nFr\u00f6ba et al., Int. J. Mol. Sci. 2021, 22, 13202<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nThe Saliva of Probands Sucking an Iota-Carrageenan Containing Lozenge Inhibits Viral Binding and Replication of the Most Predominant Common Cold Viruses and SARS-CoV-2<\/td>\r\nMorokutti-Kurz M et al., Int J Gen Med. 2021;14:5241-5249<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nIota-carrageenan neutralizes SARS-CoV-2 and inhibits viral replication in vitro<\/td>\r\nMorokutti-Kurz et al., PLoS ONE, 2021, 16(2): e0237480.<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nEfficacy of a Nasal Spray Containing Iota-Carrageenan in the Postexposure Prophylaxis of COVID-19 in Hospital Personnel Dedicated to Patients Care with COVID-19 Disease<\/td>\r\nFigueroa et al., Int J Gen Med. 2021;14:6277-6286<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nNasal therapy \u2014 The missing link in optimising strategies to improve prevention and treatment of COVID-19<\/td>\r\nRatcliffe et al., PLoS Pathog 2021; 17(11): e1010079<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nLectin from Triticum vulgaris (WGA) Inhibits Infection with SARS-CoV-2 and Its Variants of Concern Alpha and Beta<\/td>\r\nAuth, J. et al., Int. J. Mol. Sci. 2021, 22, 10205.<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nPreprint<\/td>\r\nA randomized trial – intensive treatment based in Ivermectin and Iota-Carrageenan as pre-exposure prophylaxis for Covid-19 in healthcare agents<\/td>\r\nChahla et al., medRxiv 2021; 03.26.21254398<\/td>\r\nhttps:\/\/doi.org\/10.1101\/2021.03.26.21254398<\/a><\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nReport<\/td>\r\nUse of gargle solutions and nasal sprays – two other allies in the defense against viral colds even in times of Covid-19 (German Only)<\/td>\r\nM. Suchomel et. al; Austrian Society for Hygiene, Microbiology and Preventive Medicine<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nCarrageenan nasal spray may double the rate of recovery from coronavirus and influenza virus infections: Re-analysis of randomized trial data<\/td>\r\nHemil\u00e4 et al., Pharmacology Research & Perspectives 2021<\/td>\r\nDOI: 10.1002\/prp2.810<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nGriffithsin and Carrageenan Combination Results in Antiviral Synergy against SARS-CoV-1 and 2 in a Pseudoviral Model<\/td>\r\nAlsaidi et al., Mar. Drugs 2021, 19, 418.<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nPolymeric Materials as Potential Inhibitors Against SARS-CoV-2<\/td>\r\nUmar et al., Journal of polymers and the environment, 1-20. 9 Sep. 2021<\/td>\r\ndoi:10.1007\/s10924-021-02272-6<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nNatural Derived Nasal Spray; A Proposed Approach for COVID-19 Disease Control<\/td>\r\nHoseini-Tavassol et al., Infectious Disorders – Drug Targets, 2021, 20, 1-7<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nCarrageenan containing over-the-counter nasal and oral sprays inhibit SARS-CoV-2 infection of airway epithelial cultures<\/td>\r\nSch\u00fctz et al., American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nSafety and efficacy of iota-carrageenan nasal spray in treatment and prevention of the common cold<\/td>\r\nBichiri et al., Med Pharm Rep. 2021 Jan; 94(1): 28\u201334.<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nClinical trial<\/td>\r\nPVP-I and Iota-Carrageenan Improve Subjective Clinical Symptoms In COVID-19 Emergency Hospital Wisma Atlet, Indonesia: A Single-Blind Randomized Clinical Trial.<\/td>\r\nAmtha et al., Teikyo Medical Journal; 2021, 44 (05), 1659-1669<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2021<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nVirucidal gargling and virucidal nasal spray<\/td>\r\nKramer et al., GMS Hygiene and Infection Control 2021, Vol. 16, ISSN 2196-5226<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2020<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nApplication prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines<\/td>\r\nChen et al., International Journal of Biological Macromolecules, 2020, 164, 331-343<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2020<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nStudy of the Efficacy and Safety of Topical Ivermectin + Iota-Carrageenan in the Prophylaxis against COVID-19 in Health Personnel<\/td>\r\nCarvallo et al., Journal of Biomedical Research and Clinical Investigation 2020; Volume 2 Isue 1.1007<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2020<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nSARS-CoV-2 Infection Depends on Cellular Heparan Sulfate and ACE2<\/td>\r\nClausen et al., Cell 2020, 2020.09.033<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2020<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nCarrageenans as Broad-Spectrum Microbicides: Current Status and Challenges<\/td>\r\nLee, Marine Drugs 2020, 18, 435<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2020<\/td>\r\nVirology Related<\/td>\r\nPreprint<\/td>\r\nIota-carrageenan and Xylitol inhibit SARS-CoV-2 in cell culture<\/td>\r\nBansal et al., bioRxiv. 2020; 10.1101\/2020.08.19.225854<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2020<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nCovid 19 and Ivermectin Prevention and Treatment Update<\/td>\r\nHirsch et al., Journal of Infectious Diseases & Travel Medicine 2020, 4 (S1): 000S1-007<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2020<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nThe COVID 19 novel coronavirus pandemic 2020: seaweeds to the rescue? Why does substantial, supporting research about the antiviral properties of seaweed polysaccharides seem to go unrecognized by the pharmaceutical community in these desperate times?<\/td>\r\nPereira, L., Critchley, A.T., Journal of Applied Phycology 2020<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2020<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nIota-Carrageenan as an Antiviral Treatment for the Common Cold<\/td>\r\nEccles, The Open Virology Journal 2020, 14:9<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2018<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nDevelopment of a nasal spray containing xylometazoline hydrochloride and iota- carrageenan for the symptomatic relief of nasal congestion caused by rhinitis and sinusitis<\/td>\r\nGraf et al., International Journal of General Medicine 2018, 11:275\u201328<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2017<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nAmylmetacresol\/2,4-dichlorobenzyl alcohol, hexylresorcinol, or carrageenan lozenges as active treatments for sore throat<\/td>\r\nMorokutti-Kurz et al., International Journal of General Medicine 2017, 10:53\u201360<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2015<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nThe Intranasal Application of Zanamivir and Carrageenan Is Synergistically Active against Influenza A Virus in the Murine Model<\/td>\r\nMorokutti-Kurz et al., PLOS one 2015, 10:6<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2015<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nNon-Clinical Safety Evaluation of Intranasal Iota-Carrageenan<\/td>\r\nHebar et al., PLOS one 2015, 10:4<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2015<\/td>\r\nVirology Related<\/td>\r\nJournal<\/td>\r\nEfficacy and safety of iota-carrageenan nasal spray versus placebo in early treatment of the common cold in adults: the ICICC trial<\/td>\r\nEccles et al., Respiratory Research 2015, 16:121<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2014<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nCarrageenan nasal spray in virus confirmed common cold: individual patient data analysis of two randomized controlled trials<\/td>\r\nKoenighofer et al., Multidisciplinary Respiratory Medicine 2014, 9:57<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2013<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nEfficacy of a Carrageenan nasal spray in patients with common cold: a randomized controlled trial<\/td>\r\nLudwig et al., Respiratory Research 2013, 14:124<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2013<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nCombination of a corticosteroid and an anti-viral intranasal therapy<\/td>\r\nNakowitsch et al. 2013<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2012<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nLessons learned from a double-blind randomised placebo-controlled study with a iota-carrageenan nasal spray as medical device in children with acute symptoms of common cold<\/td>\r\nFazekas et al., BMC Complementary and Alternative Medicine 2012, 12:147<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2010<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nIota-Carrageenan Is a Potent Inhibitor of Influenza A Virus Infection<\/td>\r\nLeibbrandt et al., PLOS one 2010, 5:12<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n
2010<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nEfficacy and safety of an antiviral Iota-Carrageenan nasal spray: a randomized, double-blind, placebo-controlled exploratory study in volunteers with early symptoms of the common cold<\/td>\r\nEccles et al., Respiratory Research 2010, 11:108<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n\r\n
2008<\/td>\r\nVirology Marinomed<\/td>\r\nJournal<\/td>\r\nIota-Carrageenan is a potent inhibitor of rhinovirus infection<\/td>\r\nGrassauer et al., Virology Journal 2008, 5:107<\/td>\r\n\u2014<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>\r\n<\/figure>\r\n\r\n

 <\/p>","protected":false},"excerpt":{"rendered":"

Esta lista re\u00fane as principais publica\u00e7\u00f5es cient\u00edficas sobre a iota-carragenina e suas aplica\u00e7\u00f5es nos campos da imunologia e virologia.Inclui estudos cl\u00ednicos, pr\u00e9-cl\u00ednicos e in vitro, an\u00e1lises de dados e revis\u00f5es da literatura publicadas em revistas internacionais revisadas por pares ou apresentadas em confer\u00eancias cient\u00edficas. Os trabalhos apresentados abrangem doen\u00e7as otorrinolaringol\u00f3gicas e respirat\u00f3rias, infec\u00e7\u00f5es virais (resfriados, […]<\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"","meta":{"_acf_changed":false},"topic":[215],"media_type":[165],"class_list":["post-31591","publication","type-publication","status-publish","hentry","topic-carragelose","media_type-publicacoes-cientificas"],"acf":[],"yoast_head":"\nPublica\u00e7\u00f5es cient\u00edficas sobre Carragelose\u00ae | Unither<\/title>\n<meta name=\"description\" content=\"Publica\u00e7\u00f5es cient\u00edficas sobre Carragelose\u00ae | Unither\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.unither-pharma.com\/pt-br\/publication\/carragelose-scientific-publications\/\" \/>\n<meta property=\"og:locale\" content=\"pt_BR\" \/>\n<meta property=\"og:type\" content=\"article\" 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