{"id":31691,"date":"2026-02-03T18:34:41","date_gmt":"2026-02-03T17:34:41","guid":{"rendered":"https:\/\/www.unither-pharma.com\/publication\/understanding-the-impact-of-polyunsaturated-fatty-acids-on-age-related-macular-degeneration-a-review\/"},"modified":"2026-03-18T16:07:58","modified_gmt":"2026-03-18T15:07:58","slug":"understanding-the-impact-of-polyunsaturated-fatty-acids-on-age-related-macular-degeneration-a-review","status":"publish","type":"publication","link":"https:\/\/www.unither-pharma.com\/pt-br\/publication\/understanding-the-impact-of-polyunsaturated-fatty-acids-on-age-related-macular-degeneration-a-review\/","title":{"rendered":"Compreender o impacto dos \u00e1cidos graxos poliinsaturados na degenera\u00e7\u00e3o macular relacionada \u00e0 idade"},"content":{"rendered":"

Compreendendo o impacto dos \u00e1cidos graxos poliinsaturados na degenera\u00e7\u00e3o macular relacionada \u00e0 idade: uma revis\u00e3o<\/h2>\n

Publicado em: International Journal of Molecular Sciences.<\/p>\n

Esta revis\u00e3o cient\u00edfica aprofunda a pesquisa colaborativa conduzida por equipes da Unither D\u00e9veloppement Bordeaux em conjunto com parceiros de v\u00e1rias institui\u00e7\u00f5es, incluindo a Universit\u00e9 Paris Cit\u00e9, o CNRS, o INSERM, UTCBS, Unidade de Tecnologias Qu\u00edmicas e Biol\u00f3gicas para a Sa\u00fade, Departamento de Pesquisa e Desenvolvimento (DRDP), Ag\u00eancia Geral de Equipamentos e Produtos de Sa\u00fade (AGEPS), Assist\u00eancia P\u00fablica Hospitais de Paris (AP-HP), bem como o Instituto de Ci\u00eancias Farmac\u00eauticas da Su\u00ed\u00e7a Ocidental (ISPSO) e a Escola de Ci\u00eancias Farmac\u00eauticas da Universidade de Genebra.<\/p>\n

Resumo:<\/strong> A degenera\u00e7\u00e3o macular relacionada com a idade (DMRI) \u00e9 uma patologia ocular multifatorial que destr\u00f3i os fotorreceptores da m\u00e1cula. Distinguem-se duas formas, DMRI seca e h\u00famida, com mecanismos fisiopatol\u00f3gicos diferentes. Embora os tratamentos se tenham revelado eficazes na DMRI h\u00famida, continuam a ser um fardo pesado para os doentes e cuidadores, resultando numa falta de ades\u00e3o ao tratamento por parte dos doentes. Para a DMRI seca, n\u00e3o existe nenhum tratamento realmente eficaz dispon\u00edvel na Europa. Portanto, \u00e9 essencial buscar novas abordagens. Recentemente, o uso de \u00e1cidos graxos poliinsaturados de cadeia longa e muito longa foi identificado como uma nova alternativa terap\u00eautica interessante. De fato, os n\u00edveis desses \u00e1cidos graxos, componentes essenciais dos fotorreceptores, est\u00e3o significativamente reduzidos em pacientes com DMRI. Para entender melhor essa patologia e avaliar a efic\u00e1cia de v\u00e1rias mol\u00e9culas, foram desenvolvidos modelos in vitro e in vivo que reproduzem os mecanismos de ambos os tipos de DMRI. Este artigo analisa a anatomia e o envelhecimento fisiol\u00f3gico da retina e resume os aspectos cl\u00ednicos, os mecanismos fisiopatol\u00f3gicos da DMRI e as potenciais estrat\u00e9gias de tratamento. S\u00e3o tamb\u00e9m apresentados modelos in vitro e in vivo da DMRI. Por fim, este manuscrito centra-se na aplica\u00e7\u00e3o de \u00e1cidos graxos \u00f4mega-3 para a preven\u00e7\u00e3o e o tratamento de ambos os tipos de DMRI.<\/p>\n

Palavras-chave: retina; fotorreceptores; degenera\u00e7\u00e3o macular relacionada \u00e0 idade (DMRI); \u00e1cidos graxos poliinsaturados (PUFA); \u00e1cidos graxos \u00f4mega-3; modelos in vitro de DMRI; modelos in vivo de DMRI<\/p>\n

\"\"<\/p>\n

Voc\u00ea pode baix\u00e1-lo aqui (em ingl\u00eas): Understanding_the_Impact_of_Polyunsaturated_Fatty_<\/a><\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Compreendendo o impacto dos \u00e1cidos graxos poliinsaturados na degenera\u00e7\u00e3o macular relacionada \u00e0 idade: uma revis\u00e3o Publicado em: International Journal of Molecular Sciences. Esta revis\u00e3o cient\u00edfica aprofunda a pesquisa colaborativa conduzida por equipes da Unither D\u00e9veloppement Bordeaux em conjunto com parceiros de v\u00e1rias institui\u00e7\u00f5es, incluindo a Universit\u00e9 Paris Cit\u00e9, o CNRS, o INSERM, UTCBS, Unidade de […]<\/p>\n","protected":false},"featured_media":0,"menu_order":0,"template":"","meta":{"_acf_changed":false},"topic":[162],"media_type":[165],"class_list":["post-31691","publication","type-publication","status-publish","hentry","topic-oftalmico","media_type-publicacoes-cientificas"],"acf":[],"yoast_head":"\nCompreender o impacto dos \u00e1cidos graxos poliinsaturados na degenera\u00e7\u00e3o macular relacionada \u00e0 idade | Unither<\/title>\n<meta name=\"description\" content=\"Compreender o impacto dos \u00e1cidos graxos poliinsaturados na degenera\u00e7\u00e3o macular relacionada \u00e0 idade | Unither\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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