Physiological serum, Rhinovirus and Sars-COV2

When SARS-COV2/COVID19 emerged in early 2020, the lack of knowledge about the virus led to the appearance of numerous, often contradictory, and sometimes scientifically inappropriate guidelines. Taking stock of the knowledge gained over the last two years is important, especially regarding the application of saline, nasopharyngeal lavage, and nebulization practices. A great deal of work around the world has advanced knowledge to refine the understanding of saline use in rhinology.

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Several relevant publications are summarized:

  • A: Essentials in saline pharmacology for nasal or respiratory hygiene in times of Covid19 European Journal of Pharmacology 2021 –
  • B: Rapid initation of nasal saline irrigation: hospitalizations in Covid19 patients randomized to alkalinization or povidone-iodine compared to national dataset – / Department of Emergency Medicine – Agusta University – Georgia USA / Preprint August 2021 – Not certified by peer review
  • C: Nasopharyngeal and oropharyngeal rinses with neutral electrolyzed water prevents COVID 19 in front line health professionals. A randomized open label controlled trial in a general hospital in Mexico city. – Biomedical reports 16:11,2022 – DOI: 10.3892/br.2021.1494
  • D: Interim analysis of an open-label randomized controlled trial evaluating nasal irrigations in non-hospitalized patients with coronavirus disease – Int Forum Allergy Rhinol. 2020;10,1325-1328
  • E: Nasal Irrigation in the Covid-19 Era – International Journal of clinical studies & medical case reports, September 2021 – DOI:10.46998/IJCMCR.2021.13.000314


Since COVID 19 was a new virus, the fear of the unknown and the lack of knowledge about it led to most of the prevention actions being guided by the fear of spreading the virus. Hygiene measures that have been recognized for a long time, such as washing mucous membranes with saline solutions, had been discarded as a precautionary measure, primarily because of the fear of dissemination of the virus. This risk induced a benefit-risk ratio that did not appear favorable. []

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