Unither Worldwide

We currently employ 1,500 dedicated and experienced staff over 7 industrial sites, one Innovation & Development Center and commercial offices in Paris, Brazil and China. We continue to grow globally, increasing our capacity and capability to better serve our customers’ research and manufacturing needs.

So why not take a few moments to find out more about our technologies?

7 Manufacturing
Plants

1 Dedicated R&D
Workshop

4 Commercial
Offices

Paris

Unither Pharmaceuticals

Established over 26 years ago in France, we have grown into an international business that now boasts production facilities in Europe, North America and Brazil. We are thus ideally equipped to provide contract pharmaceutical packaging technology services on an international scale, closer to your markets.  Moreover, we offer flexible collaboration models, whether you require services incorporating the development to the manufacturing of an entirely new product or are interested in new dosage forms for existing medication.

We welcome all enquiries and look forward to developing a successful partnership with you. We will be delighted to welcome you to our Paris-based office, located in the center of Paris near Opera Garnier.

Furthermore, if you wish to join our teams, go to the Career section.

Contact Paris
Unither Pharmaceuticals
3-5 rue Saint Georges
75009 Paris FRANCE
Phone: 00 33 (0) 1 44 63 51 70
Fax: 00 33 (0) 1 44 63 51 79
Email: unither@unither-pharma.com

View on the map

Amiens

LABORATOIRE UNITHER AMIENS : UNITHER HEADQUARTERS

With a current staff of 365, Amiens was the first site to specialize in the Blow-Fill-Seal (BFS) technology and now has over 26 years of experience in the technology. The site has more than 360 employees.

Huge manufacturing capacity is provided by many, and increasing numbers of high-speed BFS lines. The plant produces 1.5 billion unit-doses per year. The analytical team validates methods and performs ICH stability studies.

A unique back-up system exists between the Coutances (France) and Rochester (USA) sites, both also dedicated to BFS technology, to offer an alternative production response for certain requirements and challenges.

Blow-Fill-Seal (BFS)
Capacity: up to 2,5 billion-unit doses/year
Filling: 0.25 mL to 10 mL

Dedicated R&D team

The teams in Amiens are responsible for tech-transfer or the development of new products. They have the expertise to manage product development from the earliest stages (phases II and III). They also undertake full development of generics or medical devices.

Site specialty

– Compounding and filling with end-filtration sterilization, aseptic compounding and filling (suspensions), gel compounding, autoclaving and filling
– Non-injectable sterile, unit-dose vials Blow-Fill-Seal technology (BFS)
– Drug Products and Medical Devices

Standards & regulations

– European cGMP
– ISO 9001 and 13485

Services

– Development of manufacturing processes for new chemical entities or OTC
– Formulation and implementation of processes for generic drugs or medical devices
Analytical services (development, validation and quality control)
Phase II and III cGMP clinical batches (variable batch size)
– Packaging in sachet of clinical batches
ICH stability (pre-stability, development, clinical batches)
– Scale up and validation of manufacturing processes
cGMP batches (pre-industrial and industrial scale)

Authorizations & Certifications

This site is regularly inspected by the ANSM (French National Drug Safety Agency), the Turkish Ministry of Health, the KFDA (Korean Food Drug and Administration), the GCCDR (Gulf Central Committee for Drug Registration) and the Taiwanese authorities, among others.

Contact Amiens

Laboratoire UNITHER
151 rue Andre Durouchez
80084 Amiens FRANCE
Phone: 00 33 (0)3 22 54 73 00
Fax: 00 33 (0)3 22 54 73 10
Email: accueil_amiens[@]unither-pharma.com

How to Get There

  • road: the A16 or A1 motorway
  • rail: Amiens or TGV Haute-Picardie rail station (+30 mins by taxi)
  • air: Paris Charles-de-Gaulle Airport or Paris Beauvais-Tillé Airport (+90 mins by taxi)
View on the map

Coutances

LABORATOIRE UNITHER COUTANCES

Laboratoire Unither Coutances is a key player in the ophthalmology market, and the second site to specialize in Blow-Fill-Seal technology. The site manufactures more than 1.2 billion sterile doses each year and has more than 290 employees.

A unique back-up system exists between the Coutances (France) and Rochester (USA) sites, both also dedicated to BFS technology, to offer an alternative production response for certain requirements and challenges.

Blow-Fill-Seal (BFS)
Capacity: 1,5 billion-unit doses/year
Filling: 0.25 mL to 4 mL

Preservative-free multidose (PFMD)
Capacity: 25 million bottles/year
Filling: 5 mL, 10 mL, 11 mL, 15 mL

A dedicated R&D team

The Coutances site has a dedicated team to manage the transfer and/or development of new products.  They have the skills to manufacture clinical batches from pilot to industrial scale, including mixers for solutions, suspensions, emulsions and gels, as well as to develop generics or medical devices.

Site specialty

– Preparation, sterilization by sterilizing filtration and/or heat and aseptic filling in Blow Fill Seal and Preservative-free multidose
– Aseptic filling with final sterilizing filtration or specifically without sterilizing filtration (gels, emulsions)

Standards & Regulations

– European and USFDA Current Good Manufacturing Practices (cGMP)
– ISO 13485

Services

– Process formulation and implementation for drugs and medical devices
– Analytical services (development, validation and quality control)
– Phase II and III cGMP clinical batches (variable batch size)
– Packaging in sachet of clinical batches
– ICH stability (pre-stability, development, clinical batches)
– Scale up and validation of manufacturing processes
– cGMP batches (pre-industrial and industrial scale)
– ICH stability (registration and tracking of clinical batches)

Authorizations & Certifications

This site is regularly inspected by the ANSM (French National Drug Safety Agency), the FDA (Food Drug and Administration), ANVISA (the Brazilian agency), the Turkish Ministry of Health, the Iranian health authorities, the KFDA (Korean Food Drug and Administration), and the Ministry of Industry and Trade of the Russian Federation.

Contact Coutances

Laboratoire Unither
1, Rue de l’Arquerie
ZI de la Guérie,
50200 Coutances FRANCE
Phone: 00 33 (0)2 33 76 70 00
Fax: 00 33 (0)2 33 76 70 05
Email: accueil.coutances[@]unither-pharma.com

How to Get There

  • road: see the map
  • rail: Granville (33 km) or Carentan, Manche rail station (37 km)
  • air: Rennes (140 km) or Caen airport (100 km)
View on the map

Colomiers

UNITHER LIQUID MANUFACTURING

The Colomiers site was acquired from Sanofi in 2009, with state-of-the-art non-sterile bottled liquids, and semi-solids operations in place. Capabilities were enhanced by adding liquid stick-pack technology. The site currently has more than 190 employees.

The site has a high production capacity with several high-speed stick-pack machines delivering 340 million sticks per year, bottle lines delivering 40 million bottles per year, and suppository and pessary lines, as well as tubes. The liquid products can be manufactured in Europe, Brazil and the United States at the same time, which guarantees adaptability to meet demand on all three continents.

Liquid Stick-Pack
Capacity: 340 million sticks/year
Filling: 5 mL to 15 mL

Pharmaceutical bottles
Capacity: 40 million bottles/year
Filling: 10 mL to 300 mL
Suppositories and Pessaries
Capacity: 80 million unit doses/year
Sprays
Tubes

A dedicated R&D team

The Colomiers site has a dedicated team to manage the transfer and/or development of new products. They have the skills to manufacture clinical batches for phases II and III, as well as to develop generics or medical devices. Unither Liquid Manufacturing can provide you with regulatory support for your marketing projects.

Site specialty

– Compounding and filling of liquids and semi-solids in stick-packs, bottles and blisters (suppositories and pessaries), sprays, and nasal drops
– Solutions, suspensions, gels, emulsions, pasty dosage forms
– Drug Products and Medical Devices

Standards & Regulations

– European ANSM cGMP and cosmetics production and packaging
– ISO 13485 (LNE) Certification

Services

– Formulation and implementation of processes for drugs and medical devices
– Analytical Services (Development, Validation, and Quality Control)
– cGMP Clinical Batches Phase II and III (Medium and Large Scale)
– Primary Packaging of Clinical Batches
– ICH Stability (Pre-stability, Development, Clinical Batches)
– Scale-up and Manufacturing Process Validation
– cGMP Batches (Pilot and Industrial Scale)
ICH Stability (Clinical Batches Registration and On-going)
Liquid Stick-Packs: Unistick®
Suppositories and Pessaries
– Semi-Solid Topical in Tubes
– Liquids: Solutions and Suspensions for Oral and Topical Use in Bottles
– Drops and Sprayers

Authorizations & Certifications

This site is regularly inspected by the ANSM (French National Drug Safety Agency)) and by ANVISA (Brazilian agency) and the Russian Federation amongst others.

Contact Colomiers

Unither Liquid Manufacturing
1-3, Allée de la Neste
Z.I en Sigal – BP70319
31773 Colomiers FRANCE
Phone: 00 33 (0)5 34 51 42 00
Fax: 00 33 (0)5 34 51 42 01
Email: accueil.colomiers[@]unither-pharma.com

How to Get There

  • road: from Paris by the A10 motorway (682 km)
  • rail: Toulouse (12km), or Colomiers rail station (1 km)
  • air: Toulouse-Blagnac airport (11 km)
View on the map

Gannat

UNITHER INDUSTRIES

The Gannat site was acquired from the Créapharm Group in 2005 and already had facilities to produce hormone-based egg cells.

Its capacities were increased by adding the Blow-Fill-Seal (BFS) technology, offering both innovative and over-the-counter products. The site currently has over 140 employees.

  • Blow-Fill-Seal (BFS)
    650 million unit doses/year
    Filling: 5mL
  • Suppositories and pessaries
    160 million unit doses/year
  • Suckable tablets

A dedicated R&D team

The Gannat site has a dedicated team to manage the transfer and/or development of new products.  They have the skills to manufacture clinical batches for phase III, as well as to develop generics or medical devices.

Site Specialty

– Dry forms manufactured under low humidity conditions
– Hormone-based eggs
– Rhinology

Standards & Regulations

– ANSM’s European Current Good Manufacturing Practices (cGMP)
– Certification ISO 13485 version 2016 (LNE)

Services

– Formulation and implementation of processes for drugs
Analytical services (development and/or validation, quality control)
Phase II and III cGMP clinical batches (medium and large scale)
– Packaging of clinical batches
ICH stability (pre-stability, development, clinical batches)
– Scale-up and validation of manufacturing processes
– cGMP batches (pre-industrial and industrial scale)
ICH Stability (registration and tracking of clinical batches)

Authorizations & Certifications

This site is regularly inspected by the ANSM (National Agency for the Safety of Medicines) and the Russian Ministry of Health, as well as other authorities around the world.

Contact Gannat

Unither Industries
17 av Portes Occitanes
03800 Gannat FRANCE
Email : gannat.accueil[@]unither-pharma.com

How to Get There
road: access via the “RN 9” main road
rail: Vichy rail station (TER)
air: Clermont-Ferrand airport

View on the map

Le Haillan

UNITHER DEVELOPPEMENT BORDEAUX

Click here

The Bordeaux site was Créapharm Group’s R&D center until it was sold to Unither. It enabled us to meet the demand from pharmaceutical companies wishing to outsource product development and provides a platform for the in-house development of newly patented or non-patented technologies and formulations, which our customers can market under license.

With more than 40 employees, the site’s teams master the development of all conventional galenic forms of new chemical entities from the earliest stages (phases I and II) and can rapidly manufacture clinical batches for initial trials.

They develop several generic products each year and carry out technology transfers to Unither’s industrial sites or to sites selected by customers.

Site Specialty

– Recommendations and pharmaceutical development strategy consulting
– Pharmaceutical innovation and development (galenic formulation and analytical services)
– Clinical (phase I to IV) and commercial (orphan drugs) manufacturing

Standards & Regulations

European Current Good Manufacturing Practices (cGMP)

Galenic expertise :

– Solid forms: tablets, capsules, suppository, ovule…
– Liquid forms: solution, suspension…
– Semi-solid forms: cream, ointment…

Primary packaging: blister pack, tube, pillbox, bottles, stick-pack,…

Analytical expertise :

– Development and validation of analytical methods
– Quality control
ICH stability study

Authorizations & Certifications

This site is regularly inspected by the ANSM (French National Drug Safety Agency) and the ANSES (French Agency for Food, Environmental and Occupational Health & Safety).

It benefitted from a French tax credit from 2020 to 2024.

Contact Bordeaux

Unither Développement Bordeaux
ZI TECH ESPACE
AVENUE DE MAGUDAS
33185 LE HAILLAN FRANCE
Phone: 00 33 (0)5 56 34 20 59
Fax: 00 33 (0)5 56 47 67 84
Email: unither@unither-pharma.com

How to Get There
By road: see map (from Paris, 593km)
train: Bordeaux rail station (27 km)
plane: Bordeaux-Mérignac airport (5 km)

View on the map

SÃO PAULO

UNITHER PHARMA BRASIL: SÃO PAULO

Click here

In November 2011, we opened our first South American office in São Paulo, Brazil, in order to explore the market, expand international operations, and provide better services to our growing customer base in the region.

Contact São Paulo

Unither Pharma Brasil
Alameda Santos, 1165
CEP 01419-002
Cerqueira César – São Paulo/SP – BRASIL
Phone: +55 (11) 4081-1121
Email: unither@unither-pharma.com

View on the map

BARRETOS

Industrial Plant

Barretos, SP, Brazil
This facility was acquired from Mariol Industrial in December 2015 to establish a Brazilian manufacturing footprint. Extensive expertise in the development and manufacture of oral solids, liquids, vitamins supplements.

Liquid stick-packs
Capacity: 70 million sticks/year
Filling: 2.5 mL to 20 mL

Bottles
Capacity: 55 million pharmaceutical bottles/year
Filling: 10 mL to 300 mL

Tablets
Capacity: 900 million tablets/year

Technologies & Products

  • Dry & Liquid pharmaceutical forms: tablets, capsules, powders, granules, solutions, syrups
    and suspensions.
  • Multi-system primary packaging: Blisters, bottles, tubes, sachet and stick-packs
  • Secondary packaging including clinical labelling and international distribution network
  • Tanks: Two 4,000-liter tanks with 4,000 liters, four 2,000-liter tanks and two 1,000-liter tanks.
  • State of the art equipment: HPLC(1), GC(1), In vitro dissolution tester Apparatus I,II & IV, FT-IR spectrophotometer (1).
  • Inter-lab analytical method transfer in accordance with ICH or customized protocols
  • Container/Closure systems compatibility studies
  • Stability studies following ICH and WHO recommendations (4 rooms)
  • Scale-up and Manufacturing Process Validation
  • ICH Stability (Clinical Batches Registration and On-going)
  • Liquid Stick-Pack
  • Liquid Pharmaceutical Bottles: Solutions and Suspensions for Oral and Topical Use in Extended and Controlled Release Formulations

Authorizations & Certifications

This site is regularly inspected by ANVISA cGMP.

Contact

Unither Pharma Brasil
Av. Mário de Oliveira, 605
CEP 14781-160 Distrito Industrial II
BARRETOS/SP – BRASIL
Phone: +55 (17) 3321 0021

View on the map

North America

UNITHER MANUFACTURING LLC

Click here

This facility was acquired from UCB Pharma in October 2013 to expand our international presence.  The site now has more than 320 employees.

Our U.S. pharmaceutical laboratory at the Rochester site is responsible for the development of Phase I-III products, generics, over-the-counter medicines, branded products, Class 2, 3 and 5 controlled substances and medical devices, in the following dosage forms:

Blow-Fill-Seal (BFS)
Filling: 0.25 mL to 3.0 mL / Solution, suspension, gel, emulsion for preservative free eye drop and inhaled medication

Liquid Stick-Packs
Filling: 2.5 mL to 10 mL / Solution, suspension, gel for oral and topical application

 

Pharmaceutical bottles
Filling: 10 mL to 150 mL / solutions and suspensions for oral use (sustained and controlled release formulations)

Tablets & capsules / Hard shell capsules filled with immediate release and prolonged release mixtures

A dedicated R&D team

Our pharmaceutical company in the USA boasts a dedicated 6,000 sq. ft. cGMP pilot workshop, enabling various non-sterile oral solid and liquid formulations to be manufactured for development, process scale-up, and clinical trials. For oral liquids, batch sizes range from 0.5 to 560 L.

For controlled release bead processes, GPCG-3 and GPCG-5 processors with Wurster inserts are available. Batch sizes in these units range from approximately 1 to 25 kg. For process scale-up and commercial manufacture, two GPCG-60 units are available with 18 and 32-inch Wurster inserts for batch sizes ranging from approximately 30 to 225 kg.

Our pharmaceutical company in the USA undertakes tableting and liquid stick-pack filling operations under industrial conditions. Tablet batch sizes can range from 1.5 to 75 kg with additional equipment available in commercial manufacturing for scale-up.

Services

– Formulation, Development & transfer (BFS (Eye drops & Inhaled medication) / Liquid stick-Pack /  liquid bottles)

– Analytical Services (Development and/or Validation, Quality control)

– cGMP Clinical Batches Phase II and III (Medium and Large Scale)

– Primary Packaging of Clinical Batches

– ICH Stability (Pre-stability, Development, Clinical Batches)

– Scale-up and Manufacturing Process Validation

– Analytical Services (Quality Control)

– cGMP Clinical Batches (Pilot and Industrial Scale)

– ICH Stability (Clinical Batches Registration and On-going)

– Full service manufacturing (BFS / Liquid stick-Pack / liquid bottles / Tablets)

 

Authorizations & Certifications

The Rochester site is inspected by the FDA (Food Drug and Administration), DEA certificate, as well as: Turkish Ministry of Health, MHA (Mexico City), ANVISA (Brazilian agency) EMA (European agency), MHRA (UK) and “Health Canada“, etc.

 

Contact Rochester

Unither LLC
755 Jefferson Road
Rochester, NY 14623
Phone: +1 585-475-9000
Fax: +1 585-272-3905
Email: unither@unither-pharma.com

View on the map

Wuhan

UNITHER PHARMACEUTICAL TECHNOLOGIES (WUHAN) CO., LTD. (UPT)

Click here

In 2016, Unither Pharmaceuticals will set up a subsidiary in China to better meet the needs of the Chinese population. With the installation of a laboratory in 2020, UPT (Wuhan) now offers drug development services.

Contact China

Commercial office
C6406 Optical Valley Biological City,
N°666 High-tech Avenue, East Lake
High-tech Development Zone
Wuhan, China
Phone: +86 27 6552 5268
Mobile: +86 1879 5550 260

View on the map

NANJING

NANJING RUINIAN BEST PHARMACEUTICAL CO. LTD (NRB)

Click here

Nanjing Ruinian Best Pharmaceutical Co. Ltd (NRB) specializes in the development and production of solid and liquid form pharmaceutical products, with an annual revenue around EUR 10 million. It is based in Nanjing, Jiangsu Province, and has 130 employees. It is owned by Wuxi Jinyuan Industrial Investment Development Group Co. Ltd, an investment holding company located in Binhu district, in Wuxi.

Contact China

Nanjing Ruinian Best Pharmaceutical Co. Lt

169 Jiangjun Ave, Jiangning District, Nanjing, Jiangsu, China
Phone: +86 27 6552 5268
Mobile: +86 1879 5550 260

View on the map

Who are we?

Our history

Events